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التصنيف: antineoplastic
المادة الفعالة: tretinoin

Tretinoin is an antineoplastic retinoid used in the treatment of acute promyelocytic leukemia (APL), classified as FAB-M3 leukemia. It acts by binding to retinoic acid receptors and promoting differentiation and maturation of abnormal promyelocytes into normal blood cells. Tretinoin specifically targets leukemic cells carrying the PML-RARα fusion protein associated with APL. This mechanism helps induce remission and restore normal hematopoiesis without directly causing cytotoxic cell destruction. It is indicated for induction of remission in patients with acute promyelocytic leukemia, including the M3 variant subtype.